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Surface Modification of Cellulose Nanocrystals (CNCs) to Form a Biocompatible, Stable, and Hydrophilic Substrate for MRI

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dc.citedby9
dc.contributor.authorWhba F.en_US
dc.contributor.authorMohamed F.en_US
dc.contributor.authorIdris M.I.en_US
dc.contributor.authorYahya M.S.en_US
dc.contributor.authorid57219308028en_US
dc.contributor.authorid35847641500en_US
dc.contributor.authorid56785419200en_US
dc.contributor.authorid56287449000en_US
dc.date.accessioned2024-10-14T03:18:31Z
dc.date.available2024-10-14T03:18:31Z
dc.date.issued2023
dc.description.abstractThis study focused on surface modification of cellulose nanocrystals (CNCs) to create a biocompatible, stable, and hydrophilic substrate suitable for use as a coating agent to develop a dual-contrast composite material. The CNCs were prepared using acid hydrolysis. Hydrolysis was completed using 64% sulfuric acid at 45 �C for 1 h, which was combined with polyethylene glycol and sodium hydroxide (PEG/NaOH). The yield of samples exhibited prominent physicochemical properties. Zeta (?) potential analysis showed that the CNCs sample had excellent colloidal stability with a highly negative surface charge. Transmission electron microscopy (TEM) analysis confirmed that the CNCs sample had a rod-like morphology. On the other hand, field-emission scanning electron microscopy (FESEM) analysis showed that the acid hydrolysis process caused a significant reduction in particle size and changed surface morphology. In addition, cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH) have many noteworthy properties such as colloidal stability, small hydrodynamic size, and water dispersibility. Furthermore, the MTT assay test on Hep G2 cells demonstrated good biocompatibility of the CNCs-PEG/NaOH and did not exhibit any cytotoxic effects. Hence, CNCs-PEG/NaOH holds the potential to serve as a dual-contrast agent for MRI techniques and other biomedical applications. � 2023 by the authors.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo6316
dc.identifier.doi10.3390/app13106316
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85160856102
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85160856102&doi=10.3390%2fapp13106316&partnerID=40&md5=63ef5e9488177dffe72492bb6e1d4867
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/34227
dc.identifier.volume13
dc.publisherMDPIen_US
dc.relation.ispartofAll Open Access
dc.relation.ispartofGold Open Access
dc.sourceScopus
dc.sourcetitleApplied Sciences (Switzerland)
dc.subjectacid hydrolysis
dc.subjectcellulose nanocrystals
dc.subjectmagnetic resonance imaging (MRI)
dc.subjectmicrocrystalline cellulose
dc.subjectMTT assay
dc.subjectparticle size
dc.titleSurface Modification of Cellulose Nanocrystals (CNCs) to Form a Biocompatible, Stable, and Hydrophilic Substrate for MRIen_US
dc.typeArticleen_US
dspace.entity.typePublication
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