Publication:
Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation

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dc.contributor.authorMonica L.J.en_US
dc.contributor.authorZaemah J.en_US
dc.contributor.authorSiti Halimah S.en_US
dc.contributor.authorid57193566449en_US
dc.contributor.authorid57216965739en_US
dc.contributor.authorid57361426200en_US
dc.date.accessioned2023-05-29T09:10:54Z
dc.date.available2023-05-29T09:10:54Z
dc.date.issued2021
dc.descriptionDrug delivery; Fourier transform infrared spectroscopy; Molar ratio; Anion-exchange methods; Antibacterial drugs; Basal spacing; Double hydroxides; Drug formulations; Layered-double hydroxides; Molar ratio; Optimum concentration; Pattern analysis; Surface porosity; Antibioticsen_US
dc.description.abstractAn antibacterial drug, ciprofloxacin (Cipro) was successfully encapsulated into Ca/Allayered double hydroxide (CLDH) with molar ratio Ca/Al = 3:1 (R3) by anion exchange method at optimum concentration of 0.2 M Cipro. The successful intercalation was confirmed by patterns analysis of powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS) and accelerated surface area and porosity (ASAP) analysis. Basal spacing of CLDH synthesized in this study is 8.7 �. Due to the inclusion of Cipro into the layered CLDH, basal spacing expanded to 16.2 � in Ca/Al-Cipro-LDH (CCLDH) compare to in CLDH. The FTIR spectra of the hybrid nanocomposite show resemblance peaks of the layered double hydroxide (LDH) and Cipro, indicating the inclusion of the drug anion into the LDH interlamellae. The percentage loading of Cipro calculated from the data obtained from CHNS is 75.9% (w/w). This shows that Ca/Al-layered double hydroxide, CLDH has prospective application as the host for ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid), an antibacterial drug for a novel drug delivery formulation. � 2021 Trans Tech Publications Ltd, Switzerland.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.4028/www.scientific.net/SSP.317.233
dc.identifier.epage238
dc.identifier.scopus2-s2.0-85120521081
dc.identifier.spage233
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85120521081&doi=10.4028%2fwww.scientific.net%2fSSP.317.233&partnerID=40&md5=1eec14051dbc6e3c68512c86b3ebad56
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/26470
dc.identifier.volume317 SSP
dc.publisherTrans Tech Publications Ltden_US
dc.sourceScopus
dc.sourcetitleSolid State Phenomena
dc.titleSynthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulationen_US
dc.typeConference Paperen_US
dspace.entity.typePublication
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