Publication: Synthesis of calcium/aluminium-ciprofloxacin-layered double hydroxide for a new antibacterial drug formulation
Date
2021
Authors
Monica L.J.
Zaemah J.
Siti Halimah S.
Journal Title
Journal ISSN
Volume Title
Publisher
Trans Tech Publications Ltd
Abstract
An antibacterial drug, ciprofloxacin (Cipro) was successfully encapsulated into Ca/Allayered double hydroxide (CLDH) with molar ratio Ca/Al = 3:1 (R3) by anion exchange method at optimum concentration of 0.2 M Cipro. The successful intercalation was confirmed by patterns analysis of powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS) and accelerated surface area and porosity (ASAP) analysis. Basal spacing of CLDH synthesized in this study is 8.7 �. Due to the inclusion of Cipro into the layered CLDH, basal spacing expanded to 16.2 � in Ca/Al-Cipro-LDH (CCLDH) compare to in CLDH. The FTIR spectra of the hybrid nanocomposite show resemblance peaks of the layered double hydroxide (LDH) and Cipro, indicating the inclusion of the drug anion into the LDH interlamellae. The percentage loading of Cipro calculated from the data obtained from CHNS is 75.9% (w/w). This shows that Ca/Al-layered double hydroxide, CLDH has prospective application as the host for ciprofloxacin (1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid), an antibacterial drug for a novel drug delivery formulation. � 2021 Trans Tech Publications Ltd, Switzerland.
Description
Drug delivery; Fourier transform infrared spectroscopy; Molar ratio; Anion-exchange methods; Antibacterial drugs; Basal spacing; Double hydroxides; Drug formulations; Layered-double hydroxides; Molar ratio; Optimum concentration; Pattern analysis; Surface porosity; Antibiotics