Publication: CA19-9 and CEA biosensors in pancreatic cancer
Date
2024
Authors
Ahmadipour M.
Bhattacharya A.
Sarafbidabad M.
Syuhada Sazali E.
Krishna Ghoshal S.
Satgunam M.
Singh R.
Rezaei Ardani M.
Missaoui N.
Kahri H.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Abstract
Cancer is a complex pathophysiological condition causing millions of deaths each year. Early diagnosis is essential especially for pancreatic cancer. Existing diagnostic tools rely on circulating biomarkers such as Carbohydrate Antigen 19?9 (CA19-9) and Carcinoembryonic Antigen (CEA). Unfortunately, these markers are nonspecific and may be increased in a variety of disorders. Accordingly, diagnosis of pancreatic cancer generally involves more invasive approaches such as biopsy as well as imaging studies. Recent advances in biosensor technology have allowed the development of precise diagnostic tools having enhanced analytical sensitivity and specificity. Herein we examine these advances in the detection of cancer in general and in pancreatic cancer specifically. Furthermore, we highlight novel technologies in the measurement of CA19-9 and CEA and explore their future application in the early detection of pancreatic cancer. ? 2024 Elsevier B.V.
Description
Keywords
Biomarkers, Tumor , CA-19-9 Antigen , Carcinoembryonic Antigen , Humans , Pancreatic Neoplasms , Sensitivity and Specificity , CA 19-9 antigen , carbon , carbon nanotube , carcinoembryonic antigen , fullerene derivative , graphene , metal organic framework , metal oxide , nanomaterial , transition element , tumor marker , CA 19-9 antigen , carcinoembryonic antigen , tumor marker , antigen detection , biological trait , biotechnology , cancer mortality , carcinogenesis , classification , diagnostic imaging , early cancer diagnosis , electrochemical analysis , ellipsometry , human , invasive procedure , nonhuman , pancreas biopsy , pancreas cancer , pathophysiology , point of care testing , Raman spectrometry , Review , sensitivity and specificity , surface plasmon resonance , tumor biopsy , pancreas tumor