Publication:
Levels and diagnostic value of model-based insulin sensitivity in sepsis: A preliminary study

Simple item page
dc.citedby6
dc.contributor.authorShukeri W.F.W.M.en_US
dc.contributor.authorMat-Nor M.B.en_US
dc.contributor.authorJamaludin U.K.en_US
dc.contributor.authorSuhaimi F.en_US
dc.contributor.authorRazak N.N.A.en_US
dc.contributor.authorRalib A.M.en_US
dc.contributor.authorid57189369133en_US
dc.contributor.authorid57226799207en_US
dc.contributor.authorid55330889600en_US
dc.contributor.authorid36247893200en_US
dc.contributor.authorid37059587300en_US
dc.contributor.authorid37031770900en_US
dc.date.accessioned2023-05-29T06:51:58Z
dc.date.available2023-05-29T06:51:58Z
dc.date.issued2018
dc.descriptionantibiotic agent; corticosteroid; glucose; hypertensive factor; infusion fluid; inotropic agent; insulin; adult; Article; artificial ventilation; clinical article; cohort analysis; controlled study; diagnostic value; female; glucose blood level; hospital admission; human; inotropism; insulin dependent diabetes mellitus; insulin infusion; insulin sensitivity; intensive care unit; male; middle aged; non insulin dependent diabetes mellitus; predictive value; receiver operating characteristic; renal replacement therapy; retrospective study; sensitivity and specificity; sepsisen_US
dc.description.abstractBackground and Aims: Currently, there is a lack of real-time metric with high sensitivity and specificity to diagnose sepsis. Insulin sensitivity (SI) may be determined in real-time using mathematical glucose-insulin models; however, its effectiveness as a diagnostic test of sepsis is unknown. Our aims were to determine the levels and diagnostic value of model-based SI for identification of sepsis in critically ill patients. Materials and Methods: In this retrospective, cohort study, we analyzed SI levels in septic (n = 18) and nonseptic (n = 20) patients at 1 (baseline), 4, 8, 12, 16, 20, and 24 h of their Intensive Care Unit admission. Patients with diabetes mellitus Type I or Type II were excluded from the study. The SI levels were derived by fitting the blood glucose levels, insulin infusion and glucose input rates into the Intensive Control of Insulin-Nutrition-Glucose model. Results: The median SI levels were significantly lower in the sepsis than in the nonsepsis at all follow-up time points. The areas under the receiver operating characteristic curve of the model-based SI at baseline for discriminating sepsis from nonsepsis was 0.814 (95% confidence interval, 0.675-0.953). The optimal cutoff point of the SI test was 1.573 � 10-4 L/mu/min. At this cutoff point, the sensitivity was 77.8%, specificity was 75%, positive predictive value was 73.7%, and negative predictive value was 78.9%. Conclusions: Model-based SI ruled in and ruled out sepsis with fairly high sensitivity and specificity in our critically ill nondiabetic patients. These findings can be used as a foundation for further, prospective investigation in this area. � 2018 Indian Journal of Critical Care Medicine | Published by Wolters Kluwer - Medknow.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.4103/ijccm.IJCCM_92_18
dc.identifier.epage407
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85049197381
dc.identifier.spage402
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85049197381&doi=10.4103%2fijccm.IJCCM_92_18&partnerID=40&md5=d8c480980ef9cfded942009915437b49
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/23806
dc.identifier.volume22
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofAll Open Access, Bronze, Green
dc.sourceScopus
dc.sourcetitleIndian Journal of Critical Care Medicine
dc.titleLevels and diagnostic value of model-based insulin sensitivity in sepsis: A preliminary studyen_US
dc.typeArticleen_US
dspace.entity.typePublication
Files
Collections
SCOPUS