Publication: Levels and diagnostic value of model-based insulin sensitivity in sepsis: A preliminary study
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Date
2018
Authors
Shukeri W.F.W.M.
Mat-Nor M.B.
Jamaludin U.K.
Suhaimi F.
Razak N.N.A.
Ralib A.M.
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Medknow Publications
Abstract
Background and Aims: Currently, there is a lack of real-time metric with high sensitivity and specificity to diagnose sepsis. Insulin sensitivity (SI) may be determined in real-time using mathematical glucose-insulin models; however, its effectiveness as a diagnostic test of sepsis is unknown. Our aims were to determine the levels and diagnostic value of model-based SI for identification of sepsis in critically ill patients. Materials and Methods: In this retrospective, cohort study, we analyzed SI levels in septic (n = 18) and nonseptic (n = 20) patients at 1 (baseline), 4, 8, 12, 16, 20, and 24 h of their Intensive Care Unit admission. Patients with diabetes mellitus Type I or Type II were excluded from the study. The SI levels were derived by fitting the blood glucose levels, insulin infusion and glucose input rates into the Intensive Control of Insulin-Nutrition-Glucose model. Results: The median SI levels were significantly lower in the sepsis than in the nonsepsis at all follow-up time points. The areas under the receiver operating characteristic curve of the model-based SI at baseline for discriminating sepsis from nonsepsis was 0.814 (95% confidence interval, 0.675-0.953). The optimal cutoff point of the SI test was 1.573 � 10-4 L/mu/min. At this cutoff point, the sensitivity was 77.8%, specificity was 75%, positive predictive value was 73.7%, and negative predictive value was 78.9%. Conclusions: Model-based SI ruled in and ruled out sepsis with fairly high sensitivity and specificity in our critically ill nondiabetic patients. These findings can be used as a foundation for further, prospective investigation in this area. � 2018 Indian Journal of Critical Care Medicine | Published by Wolters Kluwer - Medknow.
Description
antibiotic agent; corticosteroid; glucose; hypertensive factor; infusion fluid; inotropic agent; insulin; adult; Article; artificial ventilation; clinical article; cohort analysis; controlled study; diagnostic value; female; glucose blood level; hospital admission; human; inotropism; insulin dependent diabetes mellitus; insulin infusion; insulin sensitivity; intensive care unit; male; middle aged; non insulin dependent diabetes mellitus; predictive value; receiver operating characteristic; renal replacement therapy; retrospective study; sensitivity and specificity; sepsis