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Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

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dc.citedby9
dc.contributor.authorOmar H.en_US
dc.contributor.authorFadaeinasab M.en_US
dc.contributor.authorTaha H.en_US
dc.contributor.authorWidyawaruyanti A.en_US
dc.contributor.authorNafiah M.A.en_US
dc.contributor.authorRachmatiah T.en_US
dc.contributor.authorid35171066800en_US
dc.contributor.authorid55662460000en_US
dc.contributor.authorid54279619100en_US
dc.contributor.authorid21835200700en_US
dc.contributor.authorid25825474900en_US
dc.contributor.authorid34168294700en_US
dc.date.accessioned2023-05-29T08:11:40Z
dc.date.available2023-05-29T08:11:40Z
dc.date.issued2020
dc.descriptionantimalarial agent; aporphine derivative; boldine; chloroquine; laetanine; laurolitsine; roemerine; sebiferine; tavoyanine A; unclassified drug; alkaloid; antimalarial agent; aporphine derivative; plant extract; antiplasmodial activity; Article; carbon nuclear magnetic resonance; controlled study; drug isolation; electrospray mass spectrometry; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; in vitro study; Lauraceae; nonhuman; Phoebe tavoyana; plant leaf; Plasmodium falciparum; proton nuclear magnetic resonance; chemical structure; Alkaloids; Antimalarials; Aporphines; Lauraceae; Molecular Structure; Plant Extracts; Plant Leaves; Plasmodium falciparumen_US
dc.description.abstractOne new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3�6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 �g/ml, respectively. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1080/10286020.2018.1553958
dc.identifier.epage60
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85063189000
dc.identifier.spage52
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063189000&doi=10.1080%2f10286020.2018.1553958&partnerID=40&md5=988d4537785527d2360318e9599a2f4a
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/25610
dc.identifier.volume22
dc.publisherTaylor and Francis Ltd.en_US
dc.sourceScopus
dc.sourcetitleJournal of Asian Natural Products Research
dc.titleAporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyanaen_US
dc.typeArticleen_US
dspace.entity.typePublication
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