Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

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Omar H.
Fadaeinasab M.
Taha H.
Widyawaruyanti A.
Nafiah M.A.
Rachmatiah T.
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Taylor and Francis Ltd.
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One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3�6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 �g/ml, respectively. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group.
antimalarial agent; aporphine derivative; boldine; chloroquine; laetanine; laurolitsine; roemerine; sebiferine; tavoyanine A; unclassified drug; alkaloid; antimalarial agent; aporphine derivative; plant extract; antiplasmodial activity; Article; carbon nuclear magnetic resonance; controlled study; drug isolation; electrospray mass spectrometry; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; in vitro study; Lauraceae; nonhuman; Phoebe tavoyana; plant leaf; Plasmodium falciparum; proton nuclear magnetic resonance; chemical structure; Alkaloids; Antimalarials; Aporphines; Lauraceae; Molecular Structure; Plant Extracts; Plant Leaves; Plasmodium falciparum