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Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide

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dc.citedby10
dc.contributor.authorJadam M.L.en_US
dc.contributor.authorSyed Mohamad S.A.en_US
dc.contributor.authorZaki H.M.en_US
dc.contributor.authorJubri Z.en_US
dc.contributor.authorSarijo S.H.en_US
dc.contributor.authorid57193566449en_US
dc.contributor.authorid57214148746en_US
dc.contributor.authorid56263397100en_US
dc.contributor.authorid35778292400en_US
dc.contributor.authorid8609580900en_US
dc.date.accessioned2023-05-29T09:08:39Z
dc.date.available2023-05-29T09:08:39Z
dc.date.issued2021
dc.descriptionaluminum derivative; calcium aluminium layered double hydroxide; calcium derivative; ciprofloxacin; drug carrier; nanocomposite; unclassified drug; anion exchange; antibacterial activity; Article; chemical structure; contact time; controlled drug release; decarboxylation; drug decomposition; drug delivery system; drug solubility; elemental analysis; Escherichia coli; evaporation; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; inductively coupled plasma atomic emission spectrometry; ion exchange; Klebsiella pneumoniae; minimum bactericidal concentration; minimum inhibitory concentration; nonhuman; pH; pore size; pore volume; porosity; Staphylococcus aureus; surface area; surface property; transmission electron microscopy; X ray diffractionen_US
dc.description.abstractA fluoroquinolone antibacterial drug, ciprofloxacin (CPX) was successfully intercalated into calcium�aluminium-layered double hydroxide (CAL) with a molar ratio of 3:1 (Ca:Al) by anion-exchange method. The successful intercalation was confirmed by powder X-ray diffraction (PXRD) pattern analysis, Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS), and inductively coupled plasma-atomic emission spectrometry (ICP-AES). The material was also characterized by using field emission scanning electron microscope (FESEM), transmission electron microscopy (TEM), and accelerated surface area and porosity (ASAP) analysis. The basal spacing of calcium-aluminium-ciprofloxacin-layered double hydroxide (CAC) synthesized in this study is 16.2 �, which resulted from the expansion of CAL due to the inclusion of CPX in the interlayer space of the CAL carrier with a loading percentage of 75.9% (w/w). The FTIR spectra of CAC show resemblance to the peaks of CAL and CPX, indicating the inclusion of the drug into the CAL interlayers. The release percentages of the drug into phosphate-buffered saline (PBS) at pH 4.8 and 7.4 are 67% and 60%, respectively, and are best described by the pseudo-second order kinetic model. The antimicrobial activity of CPX, CAL, and CAC were investigated against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. CAL has a prospective application as a new carrier for CPX. � 2020 Elsevier B.V.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo102314
dc.identifier.doi10.1016/j.jddst.2020.102314
dc.identifier.scopus2-s2.0-85099210287
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85099210287&doi=10.1016%2fj.jddst.2020.102314&partnerID=40&md5=23def9c64015b228751b517c045e84da
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/26282
dc.identifier.volume62
dc.publisherEditions de Santeen_US
dc.sourceScopus
dc.sourcetitleJournal of Drug Delivery Science and Technology
dc.titleAntibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxideen_US
dc.typeArticleen_US
dspace.entity.typePublication
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