Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide

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Jadam M.L.
Syed Mohamad S.A.
Zaki H.M.
Jubri Z.
Sarijo S.H.
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A fluoroquinolone antibacterial drug, ciprofloxacin (CPX) was successfully intercalated into calcium�aluminium-layered double hydroxide (CAL) with a molar ratio of 3:1 (Ca:Al) by anion-exchange method. The successful intercalation was confirmed by powder X-ray diffraction (PXRD) pattern analysis, Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS), and inductively coupled plasma-atomic emission spectrometry (ICP-AES). The material was also characterized by using field emission scanning electron microscope (FESEM), transmission electron microscopy (TEM), and accelerated surface area and porosity (ASAP) analysis. The basal spacing of calcium-aluminium-ciprofloxacin-layered double hydroxide (CAC) synthesized in this study is 16.2 �, which resulted from the expansion of CAL due to the inclusion of CPX in the interlayer space of the CAL carrier with a loading percentage of 75.9% (w/w). The FTIR spectra of CAC show resemblance to the peaks of CAL and CPX, indicating the inclusion of the drug into the CAL interlayers. The release percentages of the drug into phosphate-buffered saline (PBS) at pH 4.8 and 7.4 are 67% and 60%, respectively, and are best described by the pseudo-second order kinetic model. The antimicrobial activity of CPX, CAL, and CAC were investigated against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. CAL has a prospective application as a new carrier for CPX. � 2020 Elsevier B.V.
aluminum derivative; calcium aluminium layered double hydroxide; calcium derivative; ciprofloxacin; drug carrier; nanocomposite; unclassified drug; anion exchange; antibacterial activity; Article; chemical structure; contact time; controlled drug release; decarboxylation; drug decomposition; drug delivery system; drug solubility; elemental analysis; Escherichia coli; evaporation; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; inductively coupled plasma atomic emission spectrometry; ion exchange; Klebsiella pneumoniae; minimum bactericidal concentration; minimum inhibitory concentration; nonhuman; pH; pore size; pore volume; porosity; Staphylococcus aureus; surface area; surface property; transmission electron microscopy; X ray diffraction