Publication:
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studies

Simple item page
dc.citedby29
dc.contributor.authorKhan M.U.A.en_US
dc.contributor.authorYaqoob Z.en_US
dc.contributor.authorNainar M.M.A.en_US
dc.contributor.authorRazak S.I.A.en_US
dc.contributor.authorRaza M.A.en_US
dc.contributor.authorSajjad A.en_US
dc.contributor.authorHaider S.en_US
dc.contributor.authorBusra F.M.en_US
dc.contributor.authorid57195462142en_US
dc.contributor.authorid57266663600en_US
dc.contributor.authorid57266205800en_US
dc.contributor.authorid57201381533en_US
dc.contributor.authorid57190160736en_US
dc.contributor.authorid55850801600en_US
dc.contributor.authorid35728847200en_US
dc.contributor.authorid57226463504en_US
dc.date.accessioned2023-05-29T09:06:01Z
dc.date.available2023-05-29T09:06:01Z
dc.date.issued2021
dc.descriptionChitosan; Contact angle; Controlled drug delivery; Crosslinking; Fourier transform infrared spectroscopy; Graphene oxide; Hydrogels; Medical applications; Oxide films; Phase separation; Scanning electron microscopy; Surface roughness; Targeted drug delivery; Anti-bacterial activity; Atomic-force-microscopy; Cell viability; Composite hydrogels; Drug release; Hydrogels composites; PH-responsive; Poly (vinyl alcohol) (PVA); Poly(vinyl alcohol); Poly(vinyl alcohol) (PVA); Biocompatibilityen_US
dc.description.abstractThe composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) were added to develop composite hydrogels. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle was used to analyze the hydrogels. The samples were also evaluated for swelling abilities in various mediums. The drug release profile was studied in phosphate-buffered saline (PBS) at a pH of 7.4. To predict the mechanism of drug release, the data were fitted into kinetic models. Finally, antibacterial activity and cell viability data were obtained. FTIR studies revealed the successful synthesis of CS/PVA hydrogels and GO/CS/PVA in hydrogel composite. SEM showed no phase separation of the polymers, whereas AFM showed a decrease in surface roughness with an increase in GO content. 100 �L of crosslinker was the critical concentration at which the sample displayed excellent swelling and preserved its structure. Both the crosslinked and composite hydrogel showed good swelling. The most acceptable mechanism of drug release is diffusion-controlled, and it obeys Fick�s law of diffusion for drug released. The best fitting of the zero-order, Hixson-Crowell and Higuchi models supported our assumption. The GO/CS/PVA hydrogel composite showed better antibacterial and cell viability behaviors. They can be better biomaterials in biomedical applications. � 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo3124
dc.identifier.doi10.3390/polym13183124
dc.identifier.issue18
dc.identifier.scopus2-s2.0-85115330354
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85115330354&doi=10.3390%2fpolym13183124&partnerID=40&md5=6cb9012a399d25649c7d755de92db9a8
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/26007
dc.identifier.volume13
dc.publisherMDPIen_US
dc.relation.ispartofAll Open Access, Gold, Green
dc.sourceScopus
dc.sourcetitlePolymers
dc.titleChitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: Drug release, anti-microbial and cell viability studiesen_US
dc.typeArticleen_US
dspace.entity.typePublication
Files
Collections
SCOPUS