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Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch

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dc.citedby11
dc.contributor.authorSa�adon S.en_US
dc.contributor.authorAnsari M.N.M.en_US
dc.contributor.authorRazak S.I.A.en_US
dc.contributor.authorAnand J.S.en_US
dc.contributor.authorNayan N.H.M.en_US
dc.contributor.authorIsmail A.E.en_US
dc.contributor.authorKhan M.U.A.en_US
dc.contributor.authorHaider A.en_US
dc.contributor.authorid57212346603en_US
dc.contributor.authorid55489853600en_US
dc.contributor.authorid57201381533en_US
dc.contributor.authorid57206656359en_US
dc.contributor.authorid57224123892en_US
dc.contributor.authorid57200399068en_US
dc.contributor.authorid57195462142en_US
dc.contributor.authorid55506147800en_US
dc.date.accessioned2023-05-29T09:06:29Z
dc.date.available2023-05-29T09:06:29Z
dc.date.issued2021
dc.descriptionContact angle; Crystallinity; Fourier transform infrared spectroscopy; Freezing; Gelation; Nanofibers; Physicochemical properties; Polyvinyl alcohols; Scanning electron microscopy; Sodium; Tensile strength; Tensile testing; Thawing; X ray diffraction; Electrospinning techniques; Fourier transform infrared; Freeze-thaw process; Morphological structures; Physico-chemical and mechanical properties; Physico-chemical characterization; Spectroscopic technique; Transdermal drug delivery; Drug deliveryen_US
dc.description.abstractThe aim of this study is to prepare a dual layer polyvinyl (PVA) patch using a combination of electrospinning techniques and cryogelation (freeze-thaw process) then subsequently to investigate the effect of freeze-thaw cycles, nanofiber thickness, and diclofenac sodium (DS) loading on the physicochemical and mechanical properties and formulation of dual layer PVA patches composed of electrospun PVA nanofibers and PVA cryogel. After the successful preparation of the dual layer PVA patch, the prepared patch was subjected to investigation to assess the effect of freeze-thaw cycles, nanofiber thickness and percentages of DS loading on the morphology, physiochemical and mechanical properties. Various spectroscopic techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), water contact angle, and tensile tests were used to evaluate the physicochemical and mechanical properties of prepared dual layer PVA patches. The morphological structures of the dual layer PVA patch demonstrated the effectiveness of both techniques. The effect of freeze-thaw cycles, nanofiber thickness, and DS percentage loading on the crystallinity of a dual layer PVA patch was investigated using XRD analysis. The presence of a distinct DS peak in the FTIR spectrum indicates the compatibility of DS in a dual layer PVA patch through in-situ loading. All prepared patches were considered highly hydrophilic because the data obtained was less than 90? . The increasing saturation of DS within the PVA matrix increases the tensile strength of prepared patches, however decreased its elasticity. Evidently, the increasing of electrospun PVA nanofibers thickness, freeze-thaw cycles, and the DS saturation has improved the physicochemical and mechanical properties of the DS medicated dual layer PVA patches, making them a promising biomaterial for transdermal drug delivery applications. � 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo2459
dc.identifier.doi10.3390/polym13152459
dc.identifier.issue15
dc.identifier.scopus2-s2.0-85111780450
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85111780450&doi=10.3390%2fpolym13152459&partnerID=40&md5=651b686decd7c7ac0a70cd3d66acf224
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/26065
dc.identifier.volume13
dc.publisherMDPI AGen_US
dc.relation.ispartofAll Open Access, Gold, Green
dc.sourceScopus
dc.sourcetitlePolymers
dc.titlePreparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patchen_US
dc.typeArticleen_US
dspace.entity.typePublication
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