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Fractional-calculus analysis of the dynamics of CD4+ T cells and human immunodeficiency viruses

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dc.citedby2
dc.contributor.authorAlshammari A.O.en_US
dc.contributor.authorAhmad I.en_US
dc.contributor.authorJan R.en_US
dc.contributor.authorIdris S.A.en_US
dc.contributor.authorid59156924200en_US
dc.contributor.authorid57220824630en_US
dc.contributor.authorid57205596279en_US
dc.contributor.authorid57226267577en_US
dc.date.accessioned2025-03-03T07:46:35Z
dc.date.available2025-03-03T07:46:35Z
dc.date.issued2024
dc.description.abstractCombination antiretroviral Therapy (cART) is the standard treatment approach for human immunodeficiency virus (HIV), involving the use of various antiretroviral drugs to effectively suppress the virus?s replication in the body. The objective of cART is to decrease the viral load in the blood to undetectable levels, enhance the immune system?s function, and ultimately prolong the patient?s life by preventing the progression to AIDS and associated opportunistic infections. In this work, we formulated the dynamics of HIV infection, including the effects of cART, within a fractional framework. This paper presents a numerical study that investigates the complex dynamics of HIV infection in CD4+ T cells. The proposed HIV model incorporates the impact of antiretroviral medication via the Caputo?Fabrizio derivative. To comprehend the dynamics of the proposed HIV infection model, a numerical approach is employed. The dynamic behavior of the system is illustrated by examining the influence of various input parameters, aiming to capture the system?s sensitivity to these factors. Furthermore, this modeling approach highlights the interaction between the immune system and the virus. Through numerical simulations utilizing specific input values, we explore the chaotic and periodic behavior of HIV infection and provide insights into its intricate dynamics. ? The Author(s), under exclusive licence to EDP Sciences, Springer-Verlag GmbH Germany, part of Springer Nature 2024.en_US
dc.description.natureArticle in pressen_US
dc.identifier.doi10.1140/epjs/s11734-024-01192-5
dc.identifier.scopus2-s2.0-85197903313
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85197903313&doi=10.1140%2fepjs%2fs11734-024-01192-5&partnerID=40&md5=b0e6644628c52fbdc6377aa579a99576
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/37010
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.sourceScopus
dc.sourcetitleEuropean Physical Journal: Special Topics
dc.titleFractional-calculus analysis of the dynamics of CD4+ T cells and human immunodeficiency virusesen_US
dc.typeArticleen_US
dspace.entity.typePublication
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