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Label-free Dengue E protein detection using a functionalized tapered optical fiber sensor

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dc.citedby47
dc.contributor.authorMustapha Kamil Y.en_US
dc.contributor.authorAbu Bakar M.H.en_US
dc.contributor.authorMustapa M.A.en_US
dc.contributor.authorYaacob M.H.en_US
dc.contributor.authorAbidin N.H.Z.en_US
dc.contributor.authorSyahir A.en_US
dc.contributor.authorLee H.J.en_US
dc.contributor.authorMahdi M.A.en_US
dc.contributor.authorid57212503622en_US
dc.contributor.authorid57193327503en_US
dc.contributor.authorid56538400900en_US
dc.contributor.authorid55002214500en_US
dc.contributor.authorid57202624319en_US
dc.contributor.authorid26532043800en_US
dc.contributor.authorid57190622221en_US
dc.contributor.authorid7005348074en_US
dc.date.accessioned2023-05-29T06:52:50Z
dc.date.available2023-05-29T06:52:50Z
dc.date.issued2018
dc.descriptionDiagnosis; Fiber optics; Optical fibers; Optical sensors; Proteins; Viruses; Clinical management; Dimensional changes; Fundamental concepts; Optical based sensors; Quantitative assessments; Recombinant antibody; Tapered optical fiber sensors; Tapered optical fibers; Fibersen_US
dc.description.abstractThe surge of Dengue cases around the globe has intensified the demand for a reliable diagnostic method. The work demonstrates, to the best of our knowledge, the first label-free optical based sensor for detection of Dengue II E proteins. This was achieved by utilizing tapered optical fiber that has been functionalized with complementary recombinant antibodies. The fundamental concept of the sensor relies on the interaction between strong evanescent waves resulting from the dimensional change of the fiber and immune complex formed on the surface of the fiber when the virus is present. Sensitivity and detection limit values obtained with the sensor setup are 5.02 nm/nM and 1 pM, respectively, with a standard deviation value of no more than �0.4. The compact and rapid sensor is a viable alternative for label-free and quantitative assessment of the infection, which may assist in providing better clinical management and understanding of the disease. � 2017 Elsevier B.V.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1016/j.snb.2017.11.005
dc.identifier.epage828
dc.identifier.scopus2-s2.0-85034051919
dc.identifier.spage820
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85034051919&doi=10.1016%2fj.snb.2017.11.005&partnerID=40&md5=d15f5c0d89d3071561ae9cc0ccff22b3
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/23889
dc.identifier.volume257
dc.publisherElsevier B.V.en_US
dc.relation.ispartofAll Open Access, Green
dc.sourceScopus
dc.sourcetitleSensors and Actuators, B: Chemical
dc.titleLabel-free Dengue E protein detection using a functionalized tapered optical fiber sensoren_US
dc.typeArticleen_US
dspace.entity.typePublication
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