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Release behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery system

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dc.citedby4
dc.contributor.authorJadam M.L.en_US
dc.contributor.authorJubri Z.en_US
dc.contributor.authorSarijo S.H.en_US
dc.contributor.authorid57193566449en_US
dc.contributor.authorid35778292400en_US
dc.contributor.authorid8609580900en_US
dc.date.accessioned2024-10-14T03:19:35Z
dc.date.available2024-10-14T03:19:35Z
dc.date.issued2023
dc.description.abstractIntercalation of an antihypertensive drug, captopril (CPL) into zinc�aluminum-layered (ZAL) double hydroxide carrier was successfully accomplished via co-precipitation method. The resulting material was investigated by powder X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric and differential thermogravimetric�(TGA/DTG) analysis, carbon, hydrogen, nitrogen, and sulfur (CHNS) analysis, field emission scanning electron microscopy, and accelerated surface area and porosity (ASAP) analysis. High loading percentage of CPL (61.6% [w/w]) in zinc�aluminum�captopril-layered double hydroxide (ZAC) with an interlayer spacing of 9.7 � suggested the successful intercalation of CPL into the ZAL interlayer. Release percentages of the drug into Na3PO4, Na2CO3, and NaCl solutions are 48%, 30%, and 24%, respectively. Pseudo-second order kinetic model with correlation coefficient, r2 > 0.9 best defined the release behavior of CPL from ZAC nanocomposite into the aqueous media. Cytotoxicity study reveals lower toxic nature of ZAC nanohybrid (IC50 > 200��g/mL) compared to pristine CPL drug (IC50 < 200��g/mL) when tested on HUVEC and 3T3 cells. For the work described in this research, the organic-inorganic hybrid nanocomposite, ZAC could have good application in slow releases formulation of the drug delivery system. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1007/s10934-022-01333-y
dc.identifier.epage233
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85137438305
dc.identifier.spage223
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85137438305&doi=10.1007%2fs10934-022-01333-y&partnerID=40&md5=75938b3daa28293a31b8b1c28c71003e
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/34410
dc.identifier.volume30
dc.pagecount10
dc.publisherSpringeren_US
dc.sourceScopus
dc.sourcetitleJournal of Porous Materials
dc.subjectAntihypertensive drug
dc.subjectCaptopril
dc.subjectControlled release
dc.subjectDrug delivery system
dc.subjectZinc�aluminum-layered double hydroxide
dc.subjectAluminum compounds
dc.subjectControlled drug delivery
dc.subjectDrug products
dc.subjectField emission microscopes
dc.subjectFourier transform infrared spectroscopy
dc.subjectNanocomposites
dc.subjectPrecipitation (chemical)
dc.subjectTargeted drug delivery
dc.subjectThermogravimetric analysis
dc.subjectZinc
dc.subjectAntihypertensive drugs
dc.subjectCaptopril
dc.subjectControlled release
dc.subjectCoprecipitation method
dc.subjectDrug-delivery systems
dc.subjectLayered-double hydroxides
dc.subjectRelease behaviors
dc.subjectZinc aluminiums
dc.subjectZinc-aluminum
dc.subjectZinc�aluminum-layered double hydroxide
dc.subjectScanning electron microscopy
dc.titleRelease behavior and cytotoxicity of captopril-intercalated layered double hydroxide for an antihypertensive drug delivery systemen_US
dc.typeArticleen_US
dspace.entity.typePublication
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