Publication:
Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant

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dc.citedby1
dc.contributor.authorSafaei M.en_US
dc.contributor.authorMohammadi H.en_US
dc.contributor.authorBeddu S.en_US
dc.contributor.authorMozaffari H.R.en_US
dc.contributor.authorRezaei R.en_US
dc.contributor.authorSharifi R.en_US
dc.contributor.authorMoradpoor H.en_US
dc.contributor.authorFallahnia N.en_US
dc.contributor.authorEbadi M.en_US
dc.contributor.authorJamil M.S.M.en_US
dc.contributor.authorZain A.R.M.en_US
dc.contributor.authorYusop M.R.en_US
dc.contributor.authorid36612136800en_US
dc.contributor.authorid55573732500en_US
dc.contributor.authorid55812080500en_US
dc.contributor.authorid56789924600en_US
dc.contributor.authorid56958027100en_US
dc.contributor.authorid56374298500en_US
dc.contributor.authorid56605064600en_US
dc.contributor.authorid57752551100en_US
dc.contributor.authorid57204197808en_US
dc.contributor.authorid14037490700en_US
dc.contributor.authorid56109090300en_US
dc.contributor.authorid57217851414en_US
dc.date.accessioned2025-03-03T07:47:20Z
dc.date.available2025-03-03T07:47:20Z
dc.date.issued2024
dc.description.abstractMetallic dental implants have been extensively used in clinical practice due to their superior mechanical properties, biocompatibility, and aesthetic outcomes. However, their integration with the surrounding soft tissue at the mucosal region remains challenging and can cause implant failure due to the peri-implant immune microenvironment. The soft tissue integration of dental implants can be ameliorated through different surface modifications. This review discussed and summarized the current knowledge of topography-mediated immune response and topography-mediated antibacterial activity in Ti dental implants which enhance soft tissue integration and their clinical performance. For example, nanopillar-like topographies such as spinules, and spikes showed effective antibacterial activity in human salivary biofilm which was due to the lethal stretching of bacterial membrane between the nanopillars. The key findings of this review were (I) cross-talk between surface nanotopography and soft tissue integration in which the surface nanotopography can guide the perpendicular orientation of collagen fibers into connective tissue which leads to the stability of soft tissue, (II) nanotubular array could shift the macrophage phenotype from pro-inflammatory (M1) to anti-inflammatory (M2) and manipulate the balance of osteogenesis/osteoclasia, and (III) surface nanotopography can provide specific sites for the loading of antibacterial agents and metallic nanoparticles of clinical interest functionalizing the implant surface. Silver-containing nanotubular topography significantly decreased the formation of fibrous encapsulation in per-implant soft tissue and showed synergistic antifungal and antibacterial properties. Although the Ti implants with surface nanotopography have shown promising in targeting soft tissue healing in vitro and in vivo through their immunomodulatory and antibacterial properties, however, long-term in vivo studies need to be conducted particularly in osteoporotic, and diabetic patients to ensure their desired performance with immunomodulatory and antibacterial properties. The optimization of product development is another challenging issue for its clinical translation, as the dental implant with surface nanotopography must endure implantation and operation inside the dental microenvironment. Finally, the sustainable release of metallic nanoparticles could be challenging to reduce cytotoxicity while augmenting the therapeutic effects. ? 2024 Safaei et al.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.2147/IJN.S461549
dc.identifier.epage4856
dc.identifier.scopus2-s2.0-85195016362
dc.identifier.spage4835
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85195016362&doi=10.2147%2fIJN.S461549&partnerID=40&md5=17fb466f7b9bbd3ea0641081e162462d
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/37086
dc.identifier.volume19
dc.pagecount21
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofAll Open Access; Gold Open Access; Green Open Access
dc.sourceScopus
dc.sourcetitleInternational Journal of Nanomedicine
dc.subjectAnimals
dc.subjectAnti-Bacterial Agents
dc.subjectBiofilms
dc.subjectDental Implants
dc.subjectHumans
dc.subjectMetal Nanoparticles
dc.subjectSurface Properties
dc.subjectTitanium
dc.subjectantiinfective agent
dc.subjectmetal nanoparticle
dc.subjectsilver
dc.subjecttitanium
dc.subjectantiinfective agent
dc.subjecttitanium
dc.subjectantibacterial activity
dc.subjectantifungal activity
dc.subjectbacterial membrane
dc.subjectbiocompatibility
dc.subjectbiofilm
dc.subjectbone development
dc.subjectbullock
dc.subjectclinical practice
dc.subjectcollagen fiber
dc.subjectconnective tissue
dc.subjectcytotoxicity
dc.subjectencapsulation
dc.subjecthuman
dc.subjectimmune response
dc.subjectimmunomodulation
dc.subjectimmunotherapy
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectmacrophage
dc.subjectmicroenvironment
dc.subjectnonhuman
dc.subjectosteoporosis
dc.subjectpharmaceutics
dc.subjectpharmacology
dc.subjectphenotype
dc.subjectproduct development
dc.subjectreview
dc.subjectsaliva
dc.subjectsoft tissue
dc.subjectstretching
dc.subjecttissue reaction
dc.subjecttooth implant
dc.subjecttopography
dc.subjectanimal
dc.subjectbiofilm
dc.subjectchemistry
dc.subjectdrug effect
dc.subjectsurface property
dc.titleSurface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implanten_US
dc.typeReviewen_US
dspace.entity.typePublication
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