Publication: A study on biomaterial and fabrication methods for tissue engineering scaffold
Date
2013
Authors
Sughanthy Siva Andan Perumal
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Abstract
This thesis reports on the biomaterials and scaffold fabrication techniques in tissue engineering. There are different types of biomaterials and bone scaffolds fabrication techniques in tissue engineering applications. Tissue engineering is an non- conventional approach in creating artificial organs and tissues, by helping the patients to heal from bone fracture or organs malfunction by regenerating the damaged tissues. In this study, it involves the in-vitro seeding of specific human cells onto an extracellular matrix. Bioscaffolds are being developed by the various kinds of bioactive and biodegradable composite polymer in order to assist the attachment of cell, adhesion, proliferation, migrations and differentiations. The temporary bioscaffold is needed to serve as a template for the implanted cells and a physical channel to help the formation of the new tissues. Rapid prototyping technology such as direct polymer melt deposition (DPMD) method was used to fabricate scaffold design consists of complex internal architecture with high porous. Three design of scaffolds were created and each design subject to varying processing temperature. Polylactic acid (PLA) polymer was used to create the scaffolds. Scanning Electron Microscope (SEM) was used to characterize the surface and measure the pore geometry. The result shows that different type of pore size have different porosity percentage. Processing temperatures also affected the pore size and porosity of the scaffold. Further study to this project has a greater potential in the field of tissue engineering.
Description
R857.T55 S83 2013
Keywords
Tissue engineering - methods