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Comparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymers

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dc.citedby8
dc.contributor.authorChopra L.en_US
dc.contributor.authorThakur K.K.en_US
dc.contributor.authorChohan J.S.en_US
dc.contributor.authorSharma S.en_US
dc.contributor.authorIlyas R.A.en_US
dc.contributor.authorAsyraf M.R.M.en_US
dc.contributor.authorZakaria S.Z.S.en_US
dc.contributor.authorid57422629500en_US
dc.contributor.authorid57213620560en_US
dc.contributor.authorid55211273900en_US
dc.contributor.authorid57211422917en_US
dc.contributor.authorid57196328367en_US
dc.contributor.authorid57205295733en_US
dc.contributor.authorid35996197700en_US
dc.date.accessioned2023-05-29T09:37:51Z
dc.date.available2023-05-29T09:37:51Z
dc.date.issued2022
dc.descriptionAcrylic monomers; Ascorbic acid; Chitosan; Controlled drug delivery; Graft copolymers; Grafting (chemical); Hydrogels; Scanning electron microscopy; Sodium; Targeted drug delivery; Acrylamides; Crosslinked; Diclofenac sodium; Drug release; Equilibration process; Fick�s law; Graft- copolymers; PH-responsive; Sodium diclofenac; Sustainable drug release; Amidesen_US
dc.description.abstractThe hydrogels responding to pH synthesized by graft copolymerization only and then concurrent grafting and crosslinking of monomer N-isopropyl acrylamide (NIPAAM) and binary comonomers acrylamide, acrylic acid and acrylonitrile (AAm, AA and AN) onto chitosan support were explored for the percent upload and release study for anti-inflammatory diclofenac sodium drug (DS), w.r.t. time and pH. Diclofenac sodium DS was seized in polymeric matrices by the equi-libration process. The crosslinked-graft copolymers showed the highest percent uptake than graft copolymers (without crosslinker) and chitosan itself. The sustainable release of the loaded drug was studied with respect to time at pH 2.2, 7.0, 7.4 and 9.4. Among graft copolymers (without crosslink-ing), Chit-g-polymer (NIPAAM-co-AA) and Chit-g-polymer (NIPAAM-co-AN) exhibited worthy results for sustainable drug deliverance, whereas Crosslink-Chit-g-polymer (NIPAAM-co-AA) and Crosslink-Chit-g-polymer (NIPAAM-co-AAm) presented the best results for controlled/sustained release of diclofenac sodium DS with 93.86 % and 96.30 % percent release, respectively, in 6 h contact time. Therefore, the grafted and the crosslinked graft copolymers of the chitosan showed excellent delivery devices for the DS with sustainable/prolonged release in response to pH. Drug release kinetics was studied using Fick�s law. The kinetic study revealed that polymeric matrices showed the value of n as n > 1.0, hence drug release took place by non-Fickian diffusion. Hence, the present novel findings showed the multidirectional drug release rate. The morphological changes due to interwoven network structure of the crosslinked are evident by the Scanning electron microscopy (SEM) analysis. � 2022 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo2404
dc.identifier.doi10.3390/ma15072404
dc.identifier.issue7
dc.identifier.scopus2-s2.0-85127543547
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85127543547&doi=10.3390%2fma15072404&partnerID=40&md5=f6725410ac935958d7d7fa755d632c73
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/26926
dc.identifier.volume15
dc.publisherMDPIen_US
dc.relation.ispartofAll Open Access, Gold, Green
dc.sourceScopus
dc.sourcetitleMaterials
dc.titleComparative Drug Release Investigations for Diclofenac Sodium Drug (DS) by Chitosan-Based Grafted and Crosslinked Copolymersen_US
dc.typeArticleen_US
dspace.entity.typePublication
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