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Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model

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dc.citedby2
dc.contributor.authorKong C.en_US
dc.contributor.authorAziz A.I.en_US
dc.contributor.authorKakarla A.B.en_US
dc.contributor.authorKong I.en_US
dc.contributor.authorKong W.en_US
dc.contributor.authorid55851490800en_US
dc.contributor.authorid57209460263en_US
dc.contributor.authorid57209451543en_US
dc.contributor.authorid56434024800en_US
dc.contributor.authorid26531266200en_US
dc.date.accessioned2023-05-29T07:30:11Z
dc.date.available2023-05-29T07:30:11Z
dc.date.issued2019
dc.descriptionBiology; Cell proliferation; Feeding; Lactic acid; Toxicity; Biodegradable thermoplastics; Caenorhabditis elegans; Feeding activities; Mechanical and thermal properties; Poly lactic acid; Reproductive rates; Unlimited potentials; Untreated control; Grapheneen_US
dc.description.abstractGraphene has gained tremendous attention due to its unlimited potential in various applications while poly(lactic acid) (PLA) is a biodegradable thermoplastic polyester produced from fermenting corn starch. The incorporation of graphene into PLA has been proven to exhibit excellent mechanical and thermal properties. However, there are not many reports on the potential toxic effect of these materials towards living organisms. In this study, we investigated the possible toxicity of graphene and PLA-graphene in a live animal model, the nematode Caenorhabdits elegans (C. elegans). Alive adult worms were exposed directly to graphene and PLA-graphene across a range of concentrations from 50 �g/mL to 1000 �g/mL. After certain hours of exposure, the pharyngeal pumping rate (indicative of the C. elegans feeding activity), reproductive rate and lifespan of the worms were determined and compared to the untreated worm population. At all concentrations tested, both graphene and PLA-graphene do not affect the feeding rate of the nematode. Additionally, there was no significant difference between the lifespan of worms exposed to graphene and PLA-graphene as compared to the untreated control population (p>0.05). We examined the effect of graphene on nematode�s ability to reproduce and no reduction in progenies was detected (p>0.05). Taken together, our findings suggest that graphene and PLA-graphene do not possess a negative effect on the feeding activity, reproduction and overall lifespan of the host, indicating that these materials are safe to living organism at concentration up to 1000 �g/mL. � 2019 Trans Tech Publications Ltd, Switzerland.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.4028/www.scientific.net/SSP.290.101
dc.identifier.epage106
dc.identifier.scopus2-s2.0-85067820531
dc.identifier.spage101
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85067820531&doi=10.4028%2fwww.scientific.net%2fSSP.290.101&partnerID=40&md5=d4972ed4d4ebe85677aa97d6418f566c
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/25003
dc.identifier.volume290 SSP
dc.publisherTrans Tech Publications Ltden_US
dc.sourceScopus
dc.sourcetitleSolid State Phenomena
dc.titleToxicity evaluation of graphene and poly(Lactic-acid) using a nematode modelen_US
dc.typeConference Paperen_US
dspace.entity.typePublication
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