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Development of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluation

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dc.citedby14
dc.contributor.authorKhan M.U.A.en_US
dc.contributor.authorRazak S.I.A.en_US
dc.contributor.authorAnsari M.N.M.en_US
dc.contributor.authorZulkifli R.M.en_US
dc.contributor.authorAhmad Zawawi N.en_US
dc.contributor.authorArshad M.en_US
dc.contributor.authorid57195462142en_US
dc.contributor.authorid57201381533en_US
dc.contributor.authorid55489853600en_US
dc.contributor.authorid36612692200en_US
dc.contributor.authorid57221642834en_US
dc.contributor.authorid57202472817en_US
dc.date.accessioned2023-05-29T09:05:36Z
dc.date.available2023-05-29T09:05:36Z
dc.date.issued2021
dc.descriptionAcrylic monomers; Biocompatibility; Biopolymers; Body fluids; Bone; Cell culture; Contact angle; Defects; Free radical polymerization; Free radicals; Graphene; Hydrogels; Hydroxyapatite; Nanocomposites; Scaffolds (biology); Structural optimization; Tissue regeneration; Bio-based composites; Biopolymer; Bone defect; Bone graft; Bone substitutes; Bone tissue engineering; In-vitro; Nano-hydroxyapatite; Porous scaffold; Regenerative medicine; Biodegradationen_US
dc.description.abstractSeveral significant advancements in the field of bone regenerative medicine have been made in recent years. However, therapeutic options, such as bone grafts, have several drawbacks. There is a need to develop an adequate bone substitute. As a result, significant bone defects/injuries pose a severe challenge for orthopaedic and reconstructive bone tissue. We synthesized polymeric composite material from arabinoxylan (ARX), ?-glucan (BG), nano-hydroxyapatite (nHAp), graphene oxide (GO), acrylic acid (AAc) through free radical polymerization and porous scaffold fabricated using the freezedrying technique. These fabricated porous scaffolds were then coated with chitosan solution to enhance their biological activities. The complex structure of BG, nHAp, GO was studied through various characterization and biological assays. The structural, morphological, wetting and mechanical analyses were determined using FT-IR, XRD, XPS, SEM/EXD, water contact angle and UTM. The swelling (aqueous and PBS media) and degradation (PBS media) observed their behavior in contact with body fluid. The biological activities were conducted against mouse pre-osteoblast cell lines. The result found that BGH3 has desirable morphological, structural with optimum swelling, degradation, and mechanical behavior. It was also found to be cytocompatible against MC3T3-E1 cell lines. The obtained results confirmed that the fabricated polymeric scaffolds would be a potential bone substitute to regenerate defective bone with different loading bearing applications for bone tissue engineering. � 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo3611
dc.identifier.doi10.3390/polym13213611
dc.identifier.issue21
dc.identifier.scopus2-s2.0-85118104949
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85118104949&doi=10.3390%2fpolym13213611&partnerID=40&md5=ea63f0c6547f0b243a01deac8ee08c02
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/25930
dc.identifier.volume13
dc.publisherMDPIen_US
dc.relation.ispartofAll Open Access, Gold, Green
dc.sourceScopus
dc.sourcetitlePolymers
dc.titleDevelopment of biodegradable bio-based composite for bone tissue engineering: Synthesis, characterization and in vitro biocompatible evaluationen_US
dc.typeArticleen_US
dspace.entity.typePublication
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