Publication: Novel Injectable Calcium Phosphate Bone Cement from Wet Chemical Precipitation Method
Date
2017
Authors
Hablee S.
Sopyan I.
Mel M.
Salleh H.M.
Rahman M.M.
Singh R.
Journal Title
Journal ISSN
Volume Title
Publisher
Institute of Physics Publishing
Abstract
Calcium phosphate cement has been prepared via chemical precipitation method for injectable bone filling materials. Calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4, were used as calcium and phosphorus precursors respectively. The synthesized powder was mixed with water at different powder-to-liquid (P/L) ratios, which was adjusted at 0.8, 0.9, 1.0, 1.1 and 1.2. The influence of P/L ratio on the injectability, setting time and mechanical strength of calcium phosphate cement paste has been evaluated. The synthesized powder appeared as purely hydroxyapatite with nanosized and agglomerated spherical particles. All cement pastes show excellent injectability except for the paste with P/L ratio 1.2. Calcium phosphate cement with P/L ratio 1.1 shows the ideal cement for bone filler application with good injectability, the initial and final setting times of 30 min and 160 min, and the compression strength of 2.47 MPa. The result indicated that the newly developed calcium phosphate cement is physically suitable for bone filler application. This paper presents our investigation on the effect of P/L ratio on the handling and mechanical properties of calcium phosphate cement prepared via wet chemical precipitation method. � Published under licence by IOP Publishing Ltd.
Description
Bone; Bone cement; Calcium; Fillers; Nanotechnology; Precipitation (chemical); Setting; Strength of materials; Bone filling materials; Calcium phosphate bone cement; Calcium phosphate cement; Chemical precipitation method; Compression strength; Di-ammonium hydrogen phosphate; Synthesized powder; Wet-chemical precipitation; Calcium phosphate