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Synthesis and characterization of marine seagrass (Cymodocea serrulata) mediated titanium dioxide nanoparticles for antibacterial, antibiofilm and antioxidant properties

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dc.citedby10
dc.contributor.authorNarayanan M.en_US
dc.contributor.authorSrinivasan S.en_US
dc.contributor.authorGnanasekaran C.en_US
dc.contributor.authorRamachandran G.en_US
dc.contributor.authorChelliah C.K.en_US
dc.contributor.authorRajivgandhi G.en_US
dc.contributor.authorMaruthupandy M.en_US
dc.contributor.authorQuero F.en_US
dc.contributor.authorLi W.-J.en_US
dc.contributor.authorHayder G.en_US
dc.contributor.authorKhaled J.M.en_US
dc.contributor.authorArunachalam A.en_US
dc.contributor.authorManoharan N.en_US
dc.contributor.authorid58700065200en_US
dc.contributor.authorid58916230900en_US
dc.contributor.authorid57225915806en_US
dc.contributor.authorid57204557803en_US
dc.contributor.authorid57225915270en_US
dc.contributor.authorid57201259911en_US
dc.contributor.authorid54391597500en_US
dc.contributor.authorid36859665800en_US
dc.contributor.authorid57219824895en_US
dc.contributor.authorid56239664100en_US
dc.contributor.authorid55683393900en_US
dc.contributor.authorid58643178100en_US
dc.contributor.authorid25221617900en_US
dc.date.accessioned2025-03-03T07:44:08Z
dc.date.available2025-03-03T07:44:08Z
dc.date.issued2024
dc.description.abstractCymodocea serrulata mediated titanium dioxide nanoparticles (TiO2 NPs) were successfully synthesized. The XRD pattern and FTIR spectra demonstrated the crystalline structure of TiO2 NPs and the presence of phenols, flavonoids and alkaloids in the extract. Further SEM revealed that TiO2 NPs has uniform structure and spherical in shape with their size ranged from 58 to 117 nm. Antibacterial activity of TiO2 NPs against methicillin-resistant Staphylococcus aureus (MRSA) and Vibrio cholerae (V. cholerae), provided the zone of inhibition of 33.9 � 1.7 and 36.3 � 1.9 mm, respectively at 100 ?g/mL concentration. MIC of TiO2 NPs against MRSA and V. cholerae showed 84% and 87% inhibition at 180 ?g/mL and 160 ?g/mL respectively. Subsequently, the sub-MIC of V. cholerae demonstrated minimal or no impact on bacterial growth at concentration of 42.5 ?g/mL concentration. In addition, TiO2 NPs exhibited their ability to inhibit the biofilm forming V. cholerae which caused distinct morphological and intercellular damages analysed using CLSM and TEM. The antioxidant properties of TiO2 NPs were demonstrated through TAA and DPPH assays and exposed its scavenging activity with IC50 value of 36.42 and 68.85 ?g/mL which denotes its valuable antioxidant properties with potential health benefits. Importantly, the brine shrimp based lethality experiment yielded a low cytotoxic effect with 13% mortality at 100 ?g/mL. In conclusion, the multifaceted attributes of C. serrulata mediated TiO2 NPs encompassed the antibacterial, antioxidant and anti-biofilm inhibition effects with low cytotoxicity in nature were highlighted in this study and proved the bioderived TiO2 NPs could be used as a promising agent for biomedical applications. ? 2024 Elsevier Ltden_US
dc.description.natureFinalen_US
dc.identifier.ArtNo106595
dc.identifier.doi10.1016/j.micpath.2024.106595
dc.identifier.scopus2-s2.0-85186521777
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85186521777&doi=10.1016%2fj.micpath.2024.106595&partnerID=40&md5=67db0b42785874a33fe0befdd6299671
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/36716
dc.identifier.volume189
dc.publisherAcademic Pressen_US
dc.sourceScopus
dc.sourcetitleMicrobial Pathogenesis
dc.subjectAnti-Bacterial Agents
dc.subjectAntioxidants
dc.subjectBiofilms
dc.subjectMetal Nanoparticles
dc.subjectMethicillin-Resistant Staphylococcus aureus
dc.subjectNanoparticles
dc.subjectPlant Extracts
dc.subjectTitanium
dc.subjectalkaloid
dc.subjectflavonoid
dc.subjectphosphotungstic acid
dc.subjectphytochemical
dc.subjectplant extract
dc.subjectsaponin
dc.subjecttannin
dc.subjectterpenoid
dc.subjecttitanium dioxide nanoparticle
dc.subjectantiinfective agent
dc.subjectantioxidant
dc.subjectmetal nanoparticle
dc.subjectnanoparticle
dc.subjectplant extract
dc.subjecttitanium
dc.subjecttitanium dioxide
dc.subjectantibacterial activity
dc.subjectantibiofilm activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectbacterial growth
dc.subjectbiofilm
dc.subjectconfocal laser scanning microscopy
dc.subjectcontrolled study
dc.subjectcrystal structure
dc.subjectDPPH radical scavenging assay
dc.subjectenergy dispersive X ray spectroscopy
dc.subjectFourier transform infrared spectroscopy
dc.subjectKlebsiella pneumoniae
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectreliability
dc.subjectscanning electron microscopy
dc.subjectseagrass
dc.subjectStaphylococcus aureus
dc.subjecttoxicity
dc.subjecttransmission electron microscopy
dc.subjectVibrio cholerae
dc.subjectchemistry
dc.subjectmethicillin resistant Staphylococcus aureus
dc.titleSynthesis and characterization of marine seagrass (Cymodocea serrulata) mediated titanium dioxide nanoparticles for antibacterial, antibiofilm and antioxidant propertiesen_US
dc.typeArticleen_US
dspace.entity.typePublication
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