Publication:
Development of magnesium-doped biphasic calcium phosphatethrough sol-gel method

Simple item page
dc.citedby13
dc.contributor.authorToibah A.R.en_US
dc.contributor.authorSopyan I.en_US
dc.contributor.authorHamdi M.en_US
dc.contributor.authorRamesh S.en_US
dc.contributor.authorid25823382300en_US
dc.contributor.authorid23482484000en_US
dc.contributor.authorid17433807000en_US
dc.contributor.authorid41061958200en_US
dc.date.accessioned2023-12-29T07:57:32Z
dc.date.available2023-12-29T07:57:32Z
dc.date.issued2008
dc.description.abstractCalcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP), has shown to possess unique characteristics appropriate for bone replacement. Doping of magnesium ions into BCP will bring biological improvement. Magnesium ion was found to cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Therefore, the incorporation of magnesium ions into the calcium phosphate structure is of great interest for the development of artificial bone implants. Here we present magnesium-doped biphasic calcium phosphate (Mg-BCP) using chemical doping process through a solgel method. Mg-BCP was produced using calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. Magnesium nitrate was used as the source of the dopant. An ammoniacal solution of the monomers was heated until a white gel was obtained. The obtained gel was then dried and subsequently subjected to calcinations. The change in physicochemical properties has been evaluated by using XRD, FTIR, TG/DTA, and FESEM. Individual particles are of less than 100 nm in size, spherical shapes and tightly agglomerated. XRD measurement shown that the powder is Mg-doped BCP with 100% purity, and crystallinity increased with increased of Mg content. FTIR spectroscopy measurement also showed that the increment of crystallinity is directly proportional to the amount of dopant leading to the conclusion that magnesium acts as a sintering additive. This result is in good agreement with the analysis of FESEM where the particles of the Mgdoped BCP are larger as the amount of dopant increased as a result of more progressive fusion of particles. � 2008 Springer-Verlag.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1007/978-3-540-69139-6_80
dc.identifier.epage317
dc.identifier.issue1
dc.identifier.scopus2-s2.0-64649083106
dc.identifier.spage314
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-64649083106&doi=10.1007%2f978-3-540-69139-6_80&partnerID=40&md5=1ce18f8ac83d94162f0eb041cda29eb0
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/30996
dc.identifier.volume21 IFMBE
dc.pagecount3
dc.publisherSpringer Verlagen_US
dc.sourceScopus
dc.sourcetitleIFMBE Proceedings
dc.subjectBiphasic calcium phosphate
dc.subjectcharacterization
dc.subjecthydroxyapatite
dc.subjectsol-gel
dc.subjecttricalcium phosphate
dc.subjectAdditives
dc.subjectBiocompatibility
dc.subjectBiomedical engineering
dc.subjectCalcium phosphate
dc.subjectCrystallinity
dc.subjectFourier transform infrared spectroscopy
dc.subjectHydroxyapatite
dc.subjectMagnesium metallography
dc.subjectMetal ions
dc.subjectNitrates
dc.subjectParticle size analysis
dc.subjectPhysicochemical properties
dc.subjectSintering
dc.subjectSol-gel process
dc.subjectSol-gels
dc.subjectX ray diffraction
dc.subjectAmmoniacal solution
dc.subjectBiphasic calcium phosphates
dc.subjectCalcium nitrate tetra-hydrate
dc.subjectDi-ammonium hydrogen phosphate
dc.subjectIndividual particles
dc.subjectNucleation kinetics
dc.subjectOsteoblastic activity
dc.subjectTri-calcium phosphates
dc.subjectMagnesium compounds
dc.titleDevelopment of magnesium-doped biphasic calcium phosphatethrough sol-gel methoden_US
dc.typeConference paperen_US
dspace.entity.typePublication
Files
Collections
SCOPUS