Publication:
3D-printed Biphasic Calcium Phosphate Scaffold to augment cytocompatibility evaluation for load-bearing implant applications

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dc.citedby1
dc.contributor.authorAnanth K.P.en_US
dc.contributor.authorJayram N.D.en_US
dc.contributor.authorMuthusamy K.en_US
dc.contributor.authorid55770359500en_US
dc.contributor.authorid55965910000en_US
dc.contributor.authorid57561339000en_US
dc.date.accessioned2025-03-03T07:43:20Z
dc.date.available2025-03-03T07:43:20Z
dc.date.issued2024
dc.description.abstractIn this work, we developed and analyzed a biphasic calcium phosphate (BCP) bioceramic for bone regeneration using stereolithography (SLA). The SLA method is a promising additive manufacturing (AM) technique capable of creating BCp parts with high accuracy and efficiency. However, the ceramic suspension used in SLA exhibits significantly higher viscosity and is not environmentally friendly. Therefore, adequate preparation of a suspension with low viscosity and high solid loading is essential. In this paper, we optimized the effects of surfactant doses and solid loading on the BCp slurry, and initially examined the process parameters of photocuring, debinding, and sintering. The utilization of 9 wt % Disperbyk (BYK) with a 40 vol % loading of BCp bioceramics exhibited a reasonably low viscosity of 8.9 mPa�s at a shear level of 46.5 s?1. Functional and structural analyses confirmed that BCp was retained after photocuring and subsequent treatment, which were incorporated into the BYK dispersion. The 3D printed objects with different sintered temperatures, specifically at 1100 �C, 1200 �C, and 1300 �C, were further optimized. Additionally, the surface roughness, porosity, and mechanical properties of BCp green parts were systematically investigated. Most importantly, in vitro analysis of cell attachment, differentiation, and red alizarin analysis could support the application of bone regeneration. ? 2024 The Author(s)en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo100148
dc.identifier.doi10.1016/j.stlm.2024.100148
dc.identifier.scopus2-s2.0-85184601312
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85184601312&doi=10.1016%2fj.stlm.2024.100148&partnerID=40&md5=11e856ab68774b7721416a2aaf81b957
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/36601
dc.identifier.volume14
dc.publisherElsevier Inc.en_US
dc.relation.ispartofAll Open Access; Gold Open Access
dc.sourceScopus
dc.sourcetitleAnnals of 3D Printed Medicine
dc.subjectbioceramics
dc.subjectcalcium phosphate
dc.subjectcopolymer
dc.subjecthydroxyapatite
dc.subjectmolecular scaffold
dc.subjectsurfactant
dc.subjectArticle
dc.subjectbiocompatibility
dc.subjectbiodegradation
dc.subjectbone regeneration
dc.subjectbone tissue
dc.subjectcell adhesion
dc.subjectcell differentiation
dc.subjectcell proliferation
dc.subjectchemical reaction kinetics
dc.subjectcontrolled study
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimplantation
dc.subjectin vitro study
dc.subjectload bearing
dc.subjectMG-63 cell line
dc.subjectmicro-computed tomography
dc.subjectnuclear magnetic resonance imaging
dc.subjectosteoblast
dc.subjectpH measurement
dc.subjectpharmaceutics
dc.subjectpolymerization
dc.subjectporosity
dc.subjectrefraction index
dc.subjectscanning electron microscopy
dc.subjectshear rate
dc.subjectstereolithography
dc.subjectsurface property
dc.subjectthree dimensional printing
dc.subjecttissue engineering
dc.subjecttransmission electron microscopy
dc.subjectviscosity
dc.subjectX ray diffraction
dc.title3D-printed Biphasic Calcium Phosphate Scaffold to augment cytocompatibility evaluation for load-bearing implant applicationsen_US
dc.typeArticleen_US
dspace.entity.typePublication
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