Publication:
Insulin sensitivity as a model-based marker for sepsis diagnosis

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dc.citedby5
dc.contributor.authorSuhaimi F.M.en_US
dc.contributor.authorChase J.G.en_US
dc.contributor.authorPretty C.G.en_US
dc.contributor.authorShaw G.M.en_US
dc.contributor.authorRazak N.en_US
dc.contributor.authorJamaludin U.en_US
dc.contributor.authorid36247893200en_US
dc.contributor.authorid35570524900en_US
dc.contributor.authorid6508290605en_US
dc.contributor.authorid7401773560en_US
dc.contributor.authorid37059587300en_US
dc.contributor.authorid55330889600en_US
dc.date.accessioned2023-05-29T05:59:57Z
dc.date.available2023-05-29T05:59:57Z
dc.date.issued2015
dc.descriptionDiagnosis; Distribution functions; Insulin; Metabolism; Microcirculation; Patient treatment; Cumulative distribution function; High sensitivity; Insulin sensitivity; Metabolic conditions; Model-based OPC; Mortality rate; Patient condition; Real-time diagnosis; Sensitivity analysisen_US
dc.description.abstractSepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score. � 2015, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1016/j.ifacol.2015.10.168
dc.identifier.epage376
dc.identifier.issue20
dc.identifier.scopus2-s2.0-84992509216
dc.identifier.spage372
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84992509216&doi=10.1016%2fj.ifacol.2015.10.168&partnerID=40&md5=dff7a9e5ea1e5def5530b1f2fc903fe9
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/22269
dc.identifier.volume28
dc.relation.ispartofAll Open Access, Bronze
dc.sourceScopus
dc.sourcetitleIFAC-PapersOnLine
dc.titleInsulin sensitivity as a model-based marker for sepsis diagnosisen_US
dc.typeConference Paperen_US
dspace.entity.typePublication
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