Publication:
Modelling and Analysis of Vaccination Effects on Hand, Foot, and Mouth Disease Transmission Dynamics

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dc.citedby4
dc.contributor.authorMohandoss A.en_US
dc.contributor.authorChandrasekar G.en_US
dc.contributor.authorJan R.en_US
dc.contributor.authorid58131806100en_US
dc.contributor.authorid58957197800en_US
dc.contributor.authorid57205596279en_US
dc.date.accessioned2024-10-14T03:17:22Z
dc.date.available2024-10-14T03:17:22Z
dc.date.issued2023
dc.description.abstractIn this study, the transmission dynamics of hand, foot, and mouth disease (HFMD), incorporating vaccination, were comprehensively assessed. A Susceptible-Vaccinated-Exposed-Infectious-Recovered (SVEIR) model was formulated and its stability was evaluated in relation to disease-free and endemic equilibrium points. The fundamental reproduction number, R0, was derived utilizing the Next-Generation Matrix method. This work demonstrates the local and global asymptotic stability of both disease-free and endemic equilibria under defined conditions. The local stability of the disease-free equilibrium set was ascertained via the Jacobian matrix method, contingent upon certain prerequisites. Conversely, the stability of the endemic equilibrium set was affirmed using the Routh-Hurwitz criteria. In the context of global stability, a Lyapunov function was employed to establish the disease-free equilibrium case, demonstrating that the equilibrium E0 is globally asymptotically stable within region ?. Stability of the endemic equilibrium set for the susceptible and infected compartments was exhibited using Dulac�s criteria. Additionally, a sensitivity analysis was performed, revealing a significant correlation of the basic reproduction number to specific parameters, namely A, ?1, ?2, ?3, ?4, and ?. This analysis indicates that these aforementioned parameters have a substantial influence on HFMD propagation. The analytical findings were corroborated through numerical simulations which further reinforced the validity of the model. This work presents a profound exploration of HFMD transmission dynamics, offering valuable insights for the development of efficacious control strategies. � (2023) IIETA. This article is published by IIETA and is licensed under the CC BY 4.0 license.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.18280/mmep.100603
dc.identifier.epage1949
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85183556654
dc.identifier.spage1937
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85183556654&doi=10.18280%2fmmep.100603&partnerID=40&md5=3af680552ad2d14419f8c70f4a65b1cd
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/33877
dc.identifier.volume10
dc.pagecount12
dc.publisherInternational Information and Engineering Technology Associationen_US
dc.relation.ispartofAll Open Access
dc.relation.ispartofHybrid Gold Open Access
dc.sourceScopus
dc.sourcetitleMathematical Modelling of Engineering Problems
dc.subjectand mouth disease vaccination
dc.subjectdynamical behaviour
dc.subjectfoot
dc.subjecthand
dc.subjectNumerical results
dc.subjectsensitivity analysis
dc.subjectstability analysis
dc.subjectthreshold parameter
dc.titleModelling and Analysis of Vaccination Effects on Hand, Foot, and Mouth Disease Transmission Dynamicsen_US
dc.typeArticleen_US
dspace.entity.typePublication
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