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Effect of compatibilizers on in vitro biocompatibility of PLA–HA bioscaffold

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dc.citedby7
dc.contributor.authorNainar S.M.M.en_US
dc.contributor.authorBegum S.en_US
dc.contributor.authorAnsari M.N.M.en_US
dc.contributor.authorHoque M.E.en_US
dc.contributor.authorAini S.S.en_US
dc.contributor.authorNg M.H.en_US
dc.contributor.authorRuszymah B.H.I.en_US
dc.contributor.authorid56662486800en_US
dc.contributor.authorid7101852571en_US
dc.contributor.authorid55489853600en_US
dc.contributor.authorid35834864100en_US
dc.contributor.authorid56662506500en_US
dc.contributor.authorid8330324300en_US
dc.contributor.authorid8631652600en_US
dc.date.accessioned2023-05-16T02:45:37Z
dc.date.available2023-05-16T02:45:37Z
dc.date.issued2014
dc.description.abstractThis paper exclusively describes the biocompatibility evaluation of biodegradable PLA–HA-based composites as temporary bone scaffolds for bone tissue engineering in orthopaedic applications. For that purpose, a set of composites were prepared using 3D melt-deposition method that comprises a biopolymer namely polylactic acid (PLA), and a bioceramic filler, namely hydroxyapatite (HA) 10 wt%, and compatibilizers, namely poly acrylic acid (PAA) 2 wt% and maleic anhydirde (MAH) 2 wt%. The composite samples were evaluated by in vitro assays and biodegradability tests were conducted in phosphate-buffered saline (PBS). For the in vitro analysis, osteogenic-induced stem cells were seeded onto the composite scaffold. An inverted optical microscope with computerised image analysis system was used to obtain data regarding cell attachment and contact characteristics after seeding for 48 h. Results showed that the PLA–HA-based composites did not induce adverse reactions from the cells, which in addition to their bone-matching mechanical properties makes them promising materials for bone scaffold applications. © 2014, Thomas Telford Services Ltd. All rights reserved.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1680/bbn.14.00014
dc.identifier.epage216
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84930190466
dc.identifier.spage208
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84930190466&doi=10.1680%2fbbn.14.00014&partnerID=40&md5=3e54d927177d503bc7a2b4b83ee6acec
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/21830
dc.identifier.volume3
dc.publisherThomas Telford Services Ltden_US
dc.sourceScopus
dc.sourcetitleBioinspired, Biomimetic and Nanobiomaterials
dc.titleEffect of compatibilizers on in vitro biocompatibility of PLA–HA bioscaffolden_US
dc.typeArticleen_US
dspace.entity.typePublication
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