Publication:
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells

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dc.citedby5
dc.contributor.authorFadaeinasab M.en_US
dc.contributor.authorKarimian H.en_US
dc.contributor.authorOmar H.en_US
dc.contributor.authorTaha H.en_US
dc.contributor.authorkhorasani A.en_US
dc.contributor.authorBanisalam B.en_US
dc.contributor.authorAziz Ketuly K.en_US
dc.contributor.authorAbdullah Z.en_US
dc.contributor.authorid55662460000en_US
dc.contributor.authorid55314150600en_US
dc.contributor.authorid35171066800en_US
dc.contributor.authorid54279619100en_US
dc.contributor.authorid37021530300en_US
dc.contributor.authorid51061004500en_US
dc.contributor.authorid53879355900en_US
dc.contributor.authorid24767273800en_US
dc.date.accessioned2023-05-29T08:10:03Z
dc.date.available2023-05-29T08:10:03Z
dc.date.issued2020
dc.descriptionantineoplastic agent; caspase 3; caspase 7; caspase 8; caspase 9; indole alkaloid; macusine; Rauvolfia reflexa extract; Rauwolfia extract; reflexin A; unclassified drug; vinorine; flavanone derivative; indole alkaloid; reflexin; acute toxicity; antineoplastic activity; apoptosis; Article; bark; cell invasion; cell migration; cell proliferation; colon cancer; controlled study; drug isolation; drug safety; drug structure; enzyme activation; G1 phase cell cycle checkpoint; HCT 116 cell line; human; human cell; IC50; Rauvolfia reflexa; Rauwolfia; apoptosis; chemical structure; colon tumor; Apoptosis; Colonic Neoplasms; Flavanones; Humans; Indole Alkaloids; Molecular Structure; Rauwolfiaen_US
dc.description.abstractOne new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value of 30.24 � 0.75 �M. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.description.natureFinalen_US
dc.identifier.doi10.1080/10286020.2019.1588888
dc.identifier.epage488
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85063860778
dc.identifier.spage474
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063860778&doi=10.1080%2f10286020.2019.1588888&partnerID=40&md5=088cfd360c026561003fddb204617b41
dc.identifier.urihttps://irepository.uniten.edu.my/handle/123456789/25488
dc.identifier.volume22
dc.publisherTaylor and Francis Ltd.en_US
dc.sourceScopus
dc.sourcetitleJournal of Asian Natural Products Research
dc.titleReflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cellsen_US
dc.typeArticleen_US
dspace.entity.typePublication
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